Maowei Sea is a typical semi-enclosed subtropical bay where eutrophication has been rising due to human ac-tivities in recent years. At present, the source and long-term variability properties of nutrients are not well understood. This study investigated the dissolved inorganic nutrients in the riverine sections to the sea and the coastal areas from 2011 to 2017 in Qinzhou Bay (QZB), Beibu Gulf. Results showed that harmful blooms were frequent in the dry season due to rapid urbanization in recent years. During dry season, the concentrations of dissolved inorganic nitrogen (DIN) and dissolved inorganic phosphorus (DIP) increased by 67% and 150%, respectively. Most of the nutrients input to the bay were supplied by the adjoining rivers, followed by groundwater discharge according to the classical box model devised by the Land-Ocean Interactions in the Coastal Zone. High DIN concentrations in rivers were mainly caused by intensified agriculture, including urban and rural effluents, due to inadequate sanitary sewer systems. Maowei Sea (the inner bay of QZB) is a sink system for DIN but a strong source system for DIP, which surpassed riverine input, probably due to the discharge of DIP -containing effluent from the industries around the Maoling River mouth. The discrepancy in DIN and DIP sources resulted in different DIN/DIP ratios between the wet and dry seasons. P-limitation generally occurs in the wet season and is relieved in the dry season. The relief of P-limitation in the dry season may be crucial for the frequent harmful algal blooms, which may be further aggravated in the future with the rapid increase in DIP concentrations in the bay. Therefore, the results of this study provide a basis for the effective improvement of the ecological environment in the Maowei Sea.