李德海 个人简介： 1980年1月生，博士，教授，博士生导师，医药学院院长助理。教育部 _ldquo;新世纪优秀人才支持计划_rdquo;（2012）和_ldquo;山东省自然科学杰出青年基金_rdquo;获得者（2014），入选青岛海洋科学与技术国家实验室_ldquo;鳌山人才_rdquo;优秀青年学者（2015年）。被评为国家海洋局2015年度优秀科技青年（2015年）、获第九届青岛市青年科技奖（2013年）、山东省自然科学学术创新奖（2016年）。 2002年毕业于山东大学药学院，获学士学位；2002年至2007年于中国海洋大学医药学院硕博连读获药物化学博士学位（导师：顾谦群教授）；2007年7月至2009年7月在加拿大University of British Columbia进行海洋药物博士后研究（Raymond J Andersen课题组）。2009年9月经中国海洋大学_ldquo;青年英才工程_rdquo;人才引进加入医药学院天然药物化学研究室。2014年8月至2015年8月期间以访问学者身份赴美国加州大学洛杉矶分校（UCLA，Yi Tang课题组）从事真菌基因组采掘和合成生物学研究。 近年来Org.Lett.(IF: 6.579)、Eur. J. Med. Chem.(IF: 4.519)、J. Org. Chem.(IF: 4.849)、J. Nat. Prod. (IF: 3.281)等发表SCI收录论文100余篇（第一或通讯作者70余篇），已授权专利8项。目前是ACS会员；中国药学会高级会员，中国药学会海洋药物专业委员会委员、青年委员会主任；中国海洋湖沼学会药学分会副秘书长。国际期刊Org. Lett.、J. Nat. Prod.、J. Agr. Food. Chem.、RSC Adv.等20余个学术刊物审稿人。主持国家自然科学基金（3项）、山东省（3项）、教育部（1项）、国家重点实验室开放基金（2项）等9个项目，参加国家重大新药创制专项和国家_ldquo;863_rdquo;计划各1项。 联系方式： Phone: 0532-82031619 E-mail: dehaili@ouc.edu.cn 研究方向： 主要从事海洋天然药物化学研究。主要包括深远海、共附生等特殊海洋环境来源微生物功能基因和代谢产物的潜能挖掘、活性次级代谢产物发现、活性结构优化及构效关系研究。 研究项目： 国家自然科学基金（应急管理项目）：海洋微生物沉默基因激活及其活性次级代谢产物研究。项目批准号：21542001；资助金额：12万元；起止年月：2016.1.1-2016.12.31；主持人：李德海 山东省自然科学杰出青年基金计划：海洋天然药物化学，项目批准号：JQ201422；资助金额：60万元；起止年月：2014.12-2017.12；主持人：李德海 青岛海洋科学与技术国家实验室_ldquo;鳌山人才_rdquo;优秀青年学者项目：资助金额：150万元；起止年月：2015-2017.12；主持人：李德海 教育部_ldquo;新世纪优秀人才支持计划_rdquo;：药学；项目批准号：NCET-12-0499；资助金额：50万元；起止年月：2013/01-2015/12；主持人：李德海 国家自然科学基金（面上项目）：基因-活性-化学筛选指导下深海微生物活性次级代谢产物研究。项目批准号：41176120，资助金额：71万元；起止年月：2012.1.1-2015.12.31；主持人：李德海 国家自然科学基金（青年项目）：海洋放线菌Streptomyces sp.CHQ-64次级代谢产物的结构及活性多样性研究。项目批准号：21102137，资助金额：25万元；起止年月：2012.1.1-2014.12.31；主持人：李德海 高等学校博士学科点专项科研基金（新教师类）：深海来源真菌F23-2次级代谢产物的结构多样性及其抗肿瘤活性研究；项目编号：20100132120026；资助金额：3.6万元；起止年月：2011.1.1-2013.12.31；主持人：李德海 山东省优秀中青年科学家科研奖励基金计划：基于OSMAC策略的深海来源真菌次级代谢产物中抗肿瘤活性成分研究；项目编号：BS2010HZ027，资助金额：6.0万元；起止年月：2010.10-2013.12；主持人：李德海 山东省科技发展计划项目：抗肿瘤候选药物Tricitrinol B的制备及药效学研究；项目编号：2010GSF10216；资助金额：20万元；起止年月：2010.01-2012.12；主持人：李德海 发表SCI论文：(#共同第一作者；*通讯作者) Liang Qiao, Zhongwei Duan, Xiaona Wu,Dehai Li*, Qianqun Gu, and Yankai Liu*. Organocatalytic Diversity-Oriented Asymmetric Synthesis of Structurally and Stereochemically Complex Heterocycles.Org. Lett.2018, 20 (6), 1630_ndash;1633 Wenqiang Guo#, Shuai Wang#, Na Li, Feng Li, Tianjiao Zhu, Qianqun Gu, Peng Guo* andDehai Li*. Saroclides A and B, Cyclic Depsipeptides from the Mangrove-Derived Fungus Sarocladium kiliense HDN11-112.J. Nat. Prod.81 (4), 1050_ndash;1054(Most read articles) Guangwei Wu#, Xin Qi#, Xiaomei Mo, Guihong Yu, Qiang Wang, Tianjiao Zhu, Qianqun Gu, Ming Liu*, Jing Li, andDehai Li*. Structure-based Discovery of Cytotoxic Dimeric Tetrahydroxanthones as Potential Topoisomerase I Inhibitors from a Marine-derived Fungus.Eur. J. Med.Chem.2018, 148, 268_ndash;278 Feng Li, Zhenzhen Zhang, Guojian Zhang, Qian Che, Tianjiao Zhu, Qianqun Gu andDehai Li*. Determination of Taichunamide H and Structural Revision of Taichunamide A.Org. Lett.2018,20 (4), 1138_ndash;1141. Guihong Yu, Yanjuan Wang, Rilei Yu, Yanyan Feng, Lu Wang, Qian Che, Qianqun Gu, Dehai Li, Jing Li and Tianjiao Zhu*. Chetracins E and F, cytotoxic epipolythiodioxopiperazines from the marine-derived fungus Acrostalagmus luteoalbus HDN13-530.RSC Adv.2018, 8, 53-58. Xueqian He#, Zhenzhen Zhang#, Qian Che, Tianjiao Zhu, Qianqun Gu, andDehai Li *. Varilactones and Wortmannilactones Produced byPenicillium variabileCultured with Histone Deacetylase Inhibitor.Arch. Pharm. Res.2018, 41, 57-63 Feng Li#, Wenqiang Guo#, Li Wu, Tianjiao Zhu, Qianqun Gu,Dehai Li, Qian Che*. Saroclazines A-C, thio-diketopiperazines from mangrove-derived fungiSarocladium kilienseHDN11-84.Arch. Pharm. Res.2018, 41, 30-34 Guihong Yu#, Shuai Wang#, Lu Wang, Qian Che, Tianjiao Zhu, Guojian Zhang, Qianqun Gu, Peng Guo*, andDehai Li*. Lipid-Lowering Polyketides from the FungusPenicillium SteckiiHDN13-279.Mar. Drugs2018, 16, 25-37; doi:10.3390/md16010025 Zhenzhen Zhang, Xueqian He, Guojian Zhang, Qian Che, Tianjiao Zhu, Qianqun Gu, andDehai Li*. Inducing Secondary Metabolite Production by Combined Culture ofTalaromyces aculeatusandPenicillium variabile.J. Nat. Prod.2017,80 (12), 3167_ndash;3171 Zhen Yang#, Meilin Zhu#,Dehai Li*, Rong Zeng*, Bingnan Han*. N-Me-trichodermamide B isolated fromPenicillium janthinellum, with antioxidant properties through Nrf2-mediated signaling pathway.Bioorg. Med. Chem.2017, 25(24),6614-6622 Fengli Yuan, Liang Qiao, Yinghan Chen, Xin Qi, Yankai Liu,Dehai Li, Qianqun Gu, Jing Li*, Ming Liu *. AS1041, a Novel Synthesized Derivative of Marine Natural Compound Aspergiolide A, Arrests Cell Cycle, Induces Apoptosis, and Inhibits ERK Activation in K562 Cells.Mar. Drugs2017,15, 346; doi:10.3390/md15110346. Meilin Zhu, Zhen Yang, Huimin Feng, Qi Gan, Qian Che, Tianjiao Zhu, Qianqun Gu, Bingnan Han* andDehai Li*. Trichodermamides D_ndash;F, heterocyclic dipeptides with a highly functionalized 1,2-oxazadecaline core isolated from the endophytic fungusPenicillium janthinellumHDN13-309.RSC Adv., 2017, 7, 48019 _ndash; 48024. Man-Cheng Tang#, Xiaoqing Cui#, Xueqian He, Zhuang Ding, Tianjiao Zhu, Yi Tang*,Dehai Li*. Late-Stage Terpene Cyclization by an Integral Membrane Cyclase in the Biosynthesis of Isoprenoid Epoxycyclohexenone Natural Products.Org. Lett.2017, 19 (19), 5376_ndash;5379 Xiaoning Han, Zengzhi Liu, Zhenzhen Zhang, Xiaomin Zhang, Tianjiao Zhu, Qianqun Gu, Wenli Li, Qian Che*, andDehai Li*. Geranylpyrrol A and Piericidin F from Streptomycessp. CHQ-64_Delta;rdmF.J. Nat. Prod.2017, 80 (5), 1684_ndash;1687 Weiyi Zhang#, Qian Che#, Hongsheng Tan, Xin Qi, Jing Li,Dehai Li,Qianqun Gu, Tianjiao Zhu*, Ming Liu*. Marine Streptomyces sp. derived antimycin analogues suppress HeLa cells via depletion HPV E6/E7 mediated by ROS-dependent ubiquitin_ndash;proteasome system.Scientific Reports2017, 7, 42180 Meilin Zhu, Xiaomin Zhang, Huimin Feng, Jiajia Dai, Jing Li, Qian Che, Qianqun Gu, Tianjiao Zhu*, andDehai Li*. Penicisulfuranols A_ndash;F, Alkaloids from the Mangrove Endophytic FungusPenicillium janthinellumHDN13-309.J. Nat. Prod.2017, 80(1), 71-75. Feng Li, Wenqiang Guo, Qian Che, Tianjiao Zhu, Qianqun Gu, andDehai Li*. Versicones E-H and arugosin K produced by the mangrove-derived fungusAspergillus versicolorHDN11-84.J Antibiot.2017, 70, 174-178. Haibo Zhou, Xinhua Sun, Na Li, Qian Che, Tianjiao Zhu, Qianqun Gu, andDehai Li*. Isoindolone-Containing Meroperpenoids from the Endophytic FungusEmericella nidulansHDN12-249.Org. Lett.2016, 18 (18), 4670_ndash;4673. Chang-Wei Li, Ming-Wen Xia, Cheng-Bin Cui*, Jixing Peng andDehai Li. A Novel Oxaphenalenone, Penicimutalidine: Activated Production of Oxaphenalenones by the Diethyl Sulphate Mutagenesis of Marine-derived FungusPenicillium purpurogenumG59.RSC Adv.2016, 6, 82277_ndash;82281. Jixing Peng#, Xiaomin Zhang#, Wei Wang, Tianjiao Zhu, Qianqun Gu, andDehai Li*. Austalides S-U, New Meroterpenoids from the Sponge-Derived FungusAspergillus aureolatusHDN14-107.Mar. Drugs2016, 14(7), 131;doi:10.3390/md14070131 Meilin Zhu, Xiaomin Zhang, Huimin Feng, Qian Che, Tianjiao Zhu, Qianqun Gu, andDehai Li*. Campyridones A-D, pyridone alkaloids from a mangrove endophytic fungusCampylocarponsp. HDN13-307.Tetrahedron2016,72 (37), 5679_ndash;5683. Zhuang Ding, Liyuan Li, Qian Che,Dehai Li, Qianqun Gu, Tianjiao Zhu*. Richness and bioactivity of culturable soil fungi from the Fildes Peninsula, Antarctica.Extremophiles2016, 20 (4), 425_ndash;435. Zhenzhen Zhang, Xueqian He, Congcong Liu, Qian Che, Tianjiao Zhu, Qianqun Gu, andDehai Li*. Clindanones A and B and Cladosporols F and G, Polyketides from a Deep-sea Derived FungusCladosporium cladosporioidesHDN14-342.RSC Adv.2016,6, 76498-76504. Haibo Zhou#, Liyuan Li#, Chongming Wu, Tibor Kurt_aacute;n, Attila M_aacute;ndi, Yankai Liu, Qianqun Gu, Tianjiao Zhu*, Peng Guo*, andDehai Li*. Penipyridones A-F, Pyridone Alkaloids fromPenicillium funiculosum.J. Nat. Prod.2016, 79 (7), 1783_ndash;1790 Qian Che#, Hongsheng Tan#, Xiaoning Han, Xiaomin Zhang, Qianqun Gu, Tianjiao Zhu,* andDehai Li*. Naquihexcin A, aS-Bridged Pyranonaphthoquinone Dimer Bearing an Unsaturated Hexuronic Acid Moiety from a Sponge-DerivedStreptomycessp. HDN-10-293.Org. Lett.2016, 18 (14), 3358_ndash;3361. Ting Zhang, Meilin Zhu, Guangyu Sun, Na Li, Qianqun Gu,Dehai Li, Qian Che* and Tianjiao Zhu*. Exopisiod B and farylhydrazone C, two new alkaloids from the Antarctic-derived fungusPenicilliumsp. HDN14-431.J. Asian Nat. Prod. Res.2016, 18 (10), 959-965. Zhenzhen Zhang, Wenqiang Guo, Xueqian He, Qian Che, Tianjiao Zhu, Qianqun Gu,Dehai Li*. Peniphenylanes A-G from a Deep-sea Derived FungusPenicillium fellutanumHDN14-323.Planta Med.2016, 82, 872_ndash;876.(Invited Article) Qian Che, Jing Li,Dehai Li, Qianqun Gu and Tianjiao Zhu*. Structure and Absolute Configuration of Drimentine I, an Alkaloid fromStreptomycessp. CHQ-64.J Antibiot. 2016,69, 467_ndash;469. Guojian Zhang, Jing Li, Tianjiao Zhu, Qianqun Gu,Dehai Li*. Advanced tools in marine natural drug discovery.Curr. Opin. Biotech.2016,42: 13-23.(Invited Review) Guihong Yu, Guoliang Zhou, Meilin Zhu, Wei Wang, Tianjiao Zhu, Qianqun Gu andDehai Li*. Neosartoryadins A and B, Fumiquinazoline Alkaloids from a Mangrove-derived FungusNeosartorya udagawaeHDN13-313.Org. Lett.2016, 18 (2), 244_ndash;247. Zhuang Ding, Lianqing Zhang, Juan Fu, Qian Che,Dehai Li, Qianqun Gu, Tianjiao Zhu*. Phenylpyropenes E and F: new meroterpenes from the marine-derived fungusPenicillium concentricumZLQ-69.J. Antibiot. 2015,68, 748-751. Xueqian He, Zhenzhen Zhang, Yinghan Chen, Qian Che, Tianjiao Zhu, Qianqun Gu,Dehai Li*. Varitatin A, a Highly Modified Fatty Acid Amide fromPenicillium variabileCultured with a DNA Methyltransferase Inhibitor.J. Nat. Prod.2015, 78 (11), 2841_ndash;2845. Xinhua Ma, Haotian Wang, Feng Li, Zhu, Qianqun Gu, andDehai Li*. Stachybotrin G, a sulfate meroterpenoid from a sponge derived fungusStachybotrys chartarumMXH-X73.Tetrahedron Lett.2015, 56 (50), 7053_ndash;7055. Wenqiang Guo, Zhenzhen Zhang, Tianjiao Zhu, Qianqun Gu andDehai Li*. Penicyclones A-E, Antibacterial Polyketides from the Deep-sea Derived FungusPenicilliumsp. F23-2.J. Nat. Prod.2015, 78 (11), 2699_ndash;2703. Guangwei Wu#, Guihong Yu#, Tibor Kurt_aacute;n, Attila M_aacute;ndi, Jixing Peng, Xiaomei Mo, Ming Liu, Hui Li, Xinhua Sun, Jing Li, Tianjiao Zhu, Qianqun Gu, andDehai Li*. Versixanthones A_ndash;F, Cytotoxic Xanthone_ndash;Chromanone Dimers from the Marine-Derived FungusAspergillus versicolorHDN1009.J. Nat. Prod.2015, 78 (11), 2691_ndash;2698. Meilin Zhu, Huquan Gao, Chongming Wu, Tianjiao Zhu, Qian Che, Qianqun Gu, Peng Guo* andDehai Li*. Lipid-Lowering Polyketides from a Soft Coral-Derived FungusCladosporiumsp. TZP29.Bioorg. Med. Chem. Lett.2015, 25 (17), 3606_ndash;3609 Haibo Zhou, Liyuan Li, Wei Wang, Qian Che,Dehai Li, Qianqun Gu, and Tianjiao Zhu*. Chrodrimanins I and J from the Antarctic Moss-Derived FungusPenicillium funiculosumGWT2-24.J. Nat. Prod.2015, 78 (6), 1442_ndash;1445 Man-Cheng Tang, Hsiao-Ching Lin,Dehai Li, Yi Zou, Jian Li, Wei Xu, Ralph A. Cacho, Maureen E. Hillenmeyer, Neil K. Garg, Yi Tang*. Discovery of Unclustered Fungal Indole Diterpene Biosynthetic Pathways through Combinatorial Pathway Reassembly in Engineered Yeast.J. Am. Chem. Soc.2015, 137 (43), 13724-13727 Xuming Mao, Wei Xu,Dehai Li, Wenbing Yin, Yit-Heng Chooi, Yongquan Li, Yi Tang,* and Youcai Hu*. Epigenetic genome mining of an endophytic fungus leads to the pleiotropic biosynthesis of natural products.Angew. Chem. Int. Ed.2015, 54 (26), 7592_ndash;7596. Yi Zou, Zhajun Zhan,Dehai Li, Mancheng Tang, Ralph A Cacho, Kenji Watanabe, Yi Tang*. Tandem Prenyltransferases Catalyze Isoprenoid Elongation and Complexity Generation in Biosynthesis of Quinolone Alkaloids.J. Am. Chem. Soc.2015, 137 (15), 4980_ndash;4983 Shengxin Cai#, Shiwei Sun#, Jixing Peng, Xianglan Kong, Huinan Zhou, Tianjiao Zhu, Qianqun Gu, andDehai Li*. Okaramines S-U, three new indole diketopiperazine alkaloids fromAspergillus taichungensisZHN-7-07.Tetrahedron2015, 71 (21), 3715_ndash;3719.(Invited article) Qian Che#, Tong Li#, Xiaofang Liu, Tingting Yao, Jing Li, Qianqun Gu,Dehai Li*, Wenli Li*, and Tianjiao Zhu*.Genome Scanning Inspired Isolation of Reedsmycins A-F, Polyene-polyol Macrolides fromStreptomycessp. CHQ-64.RSC Adv. 2015,29 (5), 22777-22782. Xinhua Ma, Jixing Peng, Guangwei Wu, Tianjiao Zhu, Guoqiang Li, Qianqun Gu, andDehai Li*. Speradines B-D, Oxygenated Cyclopiazonic Acid Alkaloids from the Sponge-Derived FungusAspergillus flavusMXH-X104.Tetrahedron2015, 71 (21), 3522-3527. Wenqiang Guo, Xianglan Kong, Tianjiao Zhu, Qianqun Gu a andDehai Li*. Penipyrols A-B and Peniamidones A-D from the Mangrove DerivedPenicillium solitumGWQ-143.Arch. Pharm. Res.2015, 38, 1449_ndash;1454. Wenqiang Guo, Dan Li, Jixing Peng, Tianjiao Zhu, Qianqun Gu, andDehai Li*. Penicitols A-C and Penixanacid A from the Mangrove DerivedPenicillium chrysogenumHDN11-24.J. Nat. Prod.2015, 78 (2), 306_minus;310. Zhenjian Lin, Xinhua Ma, Hongjuan Wei, Dehai Li, Qianqun Gu and Tianjiao Zhu*. Spicarins A-D from Acetylated Extract of FungusSpicaria elegansKLA03.RSC Adv. 2015, 5 (44), 35262-35266. Guihong Yu, Guangwei Wu, Tianjiao Zhu, Qianqun Gu andDehai Li*. Cladosins F and G, two new hybrid polyketides from the deep-sea-derivedCladosporium sphaerospermum2005-01-E3.J. Asian Nat. Prod. Res.2015, 17 (2),120-124 Yuanyuan Wang, Xin Qi,Dehai Li,Tianjiao Zhu, Xiaomei Mo, Jing Li*. Anticancer efficacy and absorption, distribution, metabolism, and toxicity studies of Aspergiolide A in early drug development.Drug. Des. Dev. Ther.2014, 8, 1965_ndash;1977. Jixing Peng,Huquan Gao, Xiaomin Zhang, Shuai Wang, Chongming Wu,Qianqun Gu, Peng Guo,Tianjiao Zhu,*andDehai Li*.Psychrophilins E_ndash;H and Versicotide C, Cyclic Peptides from the Marine-Derived FungusAspergillus versicolorZLN-60.J. Nat. Prod.2014,77 (10), 2218-2223. Xinhua Ma, Tianjiao Zhu, Qianqun Gu, Rui Xi, Wei Wang*,Dehai Li*. Structures and antiviral activities of butyrolactone derivatives isolated from Aspergillus terreus MXH-23.J. Ocean Univ. China2014, 13 (6), 1067-1070. Xianglan Kong, Shengxin Cai, Tianjiao Zhu, Qianqun Gu,Dehai Li*, Yepeng Luana*. Secondary Metabolites and their Bioactivities of a Deep-Sea-Derived Fungus Aspergillus versicolor CXCTD-06-6a.J. Ocean Univ. China2014, 13 (4), 691-695. Jixing Peng, Huquan Gao, Jing Li, Jing Ai, Meiyu Geng, Guojian Zhang, Tianjiao Zhu, Qianqun Gu,Dehai Li*. Prenylated Indole Diketopiperazines from the Marine_ndash;Derived FungusAspergillus versicolor.J. Org. Chem.2014, 79 (17), 7895_ndash;7904. Xinhua Sun, Xianglan Kong, Huquan Gao, Tianjiao Zhu, Guangwei Wu, Qianqun Gu, andDehai Li*.Two New Meroterpenoids Produced by the Endophytic FungusPenicilliumsp. SXH-65.Arch. Pharm. Res.2014, 37, 978-982. Yepeng Luan,Hongjuan Wei,Zhenpei Zhang,Qian Che,Yankai Liu,Tianjiao Zhu,Attila M_aacute;ndi,Tibor Kurt_aacute;n,Qianqun Gu, andDehai Li*.Eleganketal A, a Highly Oxygenated Dibenzospiroketal from the Marine-Derived FungusSpicaria elegansKLA03.J. Nat. Prod.2014, 77 (7), 1718-1723. Jixing Peng, Xiaomin Zhang, Lin Du, Wei Wang, Tianjiao Zhu, Qianqun Gu, andDehai Li*. Sorbicatechols A and B, Antiviral Sorbicillinoids from the Marine-Derived FungusPenicillium chrysogenumPJX-17.J. Nat. Prod.2014, 77 (2), 424-428. Guangwei Wu, Xinhua Sun, Guihong Yu, Wei Wang, Tianjiao Zhu, Qianqun Gu, andDehai Li*. Cladosins A_minus;E, Hybrid Polyketides from a Deep-Sea-Derived Fungus,Cladosporium sphaerospermum.J. Nat. Prod.2014,77 (2), 270_ndash;275. Aiqun Lin, Guangwei Wu, Qianqun Gu, Tianjiao Zhu* andDehai Li*. New Eremophilane-type Sesquiterpenes from an Antarctic Deep-sea Derived Fungus,Penicilliumsp. PR19N-1.Arch. Pharm. Res.2014, 37, 839-844. Xinhua Ma#, Letao Li#, Tianjiao Zhu, Mingyu Ba, Guoqiang Li, Qianqun Gu, Ying Guo*andDehai Li*. Phenylspirodrimanes with Anti-HIV Activity from the Sponge-derived FungusStachybotrys chartarumMXH-X73.J. Nat. Prod.2013, 76 (12), 2298_ndash;2306. Wenqiang Guo, Jixing Peng, Tianjiao Zhu, Qianqun Gu, Robert A. Keyzers,andDehai Li*. Sorbicillamines A-E, Nitrogen Containing Sorbicillinoids from the Deep-sea Derived FungusPenicilliumsp. F23-2.J. Nat. Prod.2013, 76 (11), 2106-2112. Guojian Zhang, Guangwei Wu, Tianjiao Zhu, Tibor Kurt_aacute;n, Attila M_aacute;ndi, Jieying Jiao, Jing Li, Xin Qi, Qianqun Gu andDehai Li*. Meroterpenoids with Diverse Ring Systems from the Sponge-Associated FungusAlternariasp.JJY-32.J. Nat. Prod.2013,76 (10),1946_ndash;1957. Shiwei Sun, Changzhu Ji, Qianqun Gu,Dehai Li, and Tianjiao Zhu*.Three New Polyketides from Marine-derived FungusAspergillus glaucusHB1-19.J. Asian Nat. Prod.Res.2013,15 (9), 956-961. Jixing Peng, Tao Lin, Wei Wang, Zhihong Xin,* Tianjiao Zhu, Qianqun Gu, andDehai Li*. Antiviral Alkaloids Produced by the Mangrove-Derived FungusCladosporiumsp. PJX-41.J. Nat. Prod.2013, 76 (6), 1133-1140. Huquan Gao#, Lina Zhou#, Shengxin Cai, Guojian Zhang, Tianjiao Zhu, Qianqun GuandDehai Li*. Diorcinols B-E, new prenylated diphenyl ethers from the marine-derived fungusAspergillus versicolorZLN-60.J. Antibiot.2013, 66, 539-542. Huquan Gao, Lina Zhou,Dehai Li, Qianqun Gu, and Tianjiao Zhu*. New Cytotoxic Metabolites from the Marine-Derived FungusPenicilliumsp. ZLN29.Helv. Chim. Acta.2013,96, 514-519. Guangwei Wu#, Aiqun Lin#, Qianqun Gu, Tianjiao Zhu* andDehai Li*. Four new chloro-eremophilane sesquiterpenes from an Antarctic deep-sea derived fungus,Penicilliumsp. PR19N-1.Mar. Drugs2013, 11,1399-1408. Shengxin Cai, Yepeng Luan, Xianglan Kong, Tianjiao Zhu, Qianqun Gu, andDehai Li*. Isolation and photoinduced conversion of 6-epi-Stephacidins fromAspergillus taichungensis.Org. Lett. 2013, 15 (9), 2168-2171. Qian Che, Tianjiao Zhu, Robert A. Keyzers, Xiaofang Liu, Jing Li, Qianqun Gu, andDehai Li*.Polycyclichybridisoprenoids from areedrhizosphere-soilderivedStreptomycessp. CHQ-64.J. Nat. Prod.2013, 76 (4), 759-763. Xianglan Kong, Xinhua Ma, Yunying Xie, Shengxin Cai, Tianjiao Zhu, Qianqun Gu , andDehai Li*.Aromatic Polyketides from a Sponge-derived FungusMetarhizium anisopliaemxh-99 and Their Antitubercular Activities.Arch. Pharm. Res.2013,36 (6), 739-744. Huquan Gao, Tianjiao Zhu,Dehai Li, Qianqun Gu, Weizhong Liu*. Prenylated indole diketopiperazine alkaloids from a mangrove rhizosphere soil derived fungusAspergillus effusesH1-1.Arch. Pharm. Res.2013, 36 (8), 952-956. Xinying Yang, Guojian Zhang, Xuelian Tang, Jieying Jiao, Sung Yeon Kim, Joo Young Lee, Tianjiao Zhu,Dehai Li, Yong Gab Yun, Qianqun Gu*, Hyun Park*. Toll-like receptor 4/nuclear factor-_kappa;B signaling pathway is involved in ACTG-toxin H-mediated anti-inflammatory effect.Mol. Cell Biochem.2013, 374, 29_ndash;36. Huquan Gao, Wenqiang Guo, Qiang Wang, Lianqing Zhang, Meilin Zhu, Tianjiao Zhu, Qianqun Gu, Wei Wang*,Dehai Li*. Aspulvinones from a Mangrove Rhizosphere Soil-derived FungusAspergillus terreusGwq-48 with Anti-influenza A viral (H1N1) Activity.Bioorg. Med. Chem. Lett.2013,23, 1776-1778. Huquan Gao#, Weizhong Liu#,Tianjiao Zhu, Xiaomei Mo, Attila M_aacute;ndi, Tibor Kurt_aacute;n,* Jing Li,* Jing Ai, Qianqun Gu, andDehai Li*.Diketopiperazine Alkaloids from a Mangrove Rhizosphere Soil Derived Fungus Aspergillus effuses H1-1.Org. Biomol. Chem.2012,10 (47), 9501-9506. Guangwei Wu,Hongyan Ma,Tianjiao Zhu,Jing Li,Qianqun Gu, andDehai Li*.Penilactones A and B, Two Novel Polyketides from Antarctic Deep-sea Derived FungusPenicillium crustosumPRB-2.Tetrahedron2012, 68 (47),9745_ndash;9749. Huquan Gao, Lianqing Zhang, Tianjiao Zhu, Qianqun Gu,Dehai Li*. Unusual Pyrrolyl 4-quinolinone Alkaloids from the Marine-Derived FungusPenicilliumsp. ghq208.Chem. Pharm. Bull.2012,60 (11),1458-1460 Xueping Li, Guojian Zhang, Tianjiao Zhu,Dehai Li, andQianqun Gu*.Strain and Culture Medium Optimization for Production Enhancement of Prodiginines from Marine-DerivedStreptomycessp. GQQ-10.J. Ocean U. China2012, 11 (3), 361-365. Qian Che, Tianjiao Zhu, Xin Qi,Attila M_aacute;ndi,Tibor Kurt_aacute;n, Xiaomei Mo, Jing Li,Qianqun Gu, andDehai Li*.Hybrid Isoprenoids from a Reeds Rhizosphere Soil Derived ActinomyceteStreptomycessp. CHQ-64.Org. Lett. 2012, 14 (13), 3438-3441. Liyuan Li,Dehai Li, Yepeng Luan, Qianqun Gu and Tianjiao Zhu*.Cytotoxic metabolites from the antarctic psychrophilic fungusOidiodendron truncatum.J. Nat. Prod.2012, 75 (5), 920-927. Jixing Peng, Jieying Jiao, Jing Li, Wei Wang, Qianqun Gu, Tianjiao Zhu*,Dehai Li*. Pyronepolyene C-glucosides with NF-_kappa;B inhibitory and anti-influenza A viral (H1N1) activities from the sponge-associated fungusEpicoccum sp.JJY40.Bioorg. Med. Chem. Lett.2012,22 (9), 3188-3190. Shengxin Cai, Xianglan Kong, Wei Wang, Huinan Zhou, Tianjiao Zhu,Dehai Li*, Qianqun Gu*. Aspergilazine A, a Diketopiperazine Dimer with a Rare N-1 to C-6 Linkage, from a Marine-derived FungusAspergillus taichungensis.Tetrahedron Lett.2012, 53 (21), 2615-2617. Li Chen, Tianjiao Zhu, Yuanqing Ding, Ikhlas A. Khan*, Qianqun Gu, andDehai Li*. Sorbiterrin A, a novel sorbicillin derivative with cholinesterase inhibition activity from the marine-derived fungusPenicillium terrestre.Tetrahedron Lett.2012,53 (3), 325-328. Dehai Li, Li Chen, Tianjiao Zhu, Tibor Kurt_aacute;n,*Attila M_aacute;ndi, Zhimin Zhao, Jing Li,*and Qianqun Gu*. Chloctanspirones A and B, novel chlorinated polyketides with an unprecedented skeleton, from marine sediment derived fungusPenicillium terrestre.Tetrahedron2011, 67 (41), 7913-7918. Lin Du#, Hongchun Liu#, Wei Fu#,Dehai Li, Qiuming Pan, Tianjiao Zhu, Meiyu Geng*, and Qianqun Gu*. Unprecedented citrinin trimer tricitinol B functions as a novel topoisomerase Ii_alpha; inhibitor.J. Med. Chem. 2011, 54, 5796-5810. Jingyan Gu#, Wenjun Han#, Fangfang Qi, Jing Li, Shiwei Sun, Tianjiao Zhu, Wenjun Mao, Qianqun Gu andDehai Li*. Two new 23-membered macrolactones from a terrestrial bacterium,Streptomycessp. IMBJ01.Helv. Chim. Acta.2011,94, 1448-1453. Huinan Zhou, Tianjiao Zhu, Shengxin Cai, Qianqun Gu andDehai Li*. Drimane sesquiterpenoids from the mangrove-derived fungusAspergillus ustus.Chem. Pharm. Bull.2011, 59 (6), 762-766. Guojian Zhang, Shiwei Sun, Tianjiao Zhu, Zhenjian Lin, Jingyan Gu,Dehai Li* and Qianqun Gu*. Antiviral isoindolone derivatives from an endophytic fungusEmericellasp. associated with mangroveAegiceras corniculatum.Phytochemistry2011, 72, 1436-1442. Lina Zhou#, Huquan Gao#, Shengxin Cai, Tianjiao Zhu , Qianqun Gu , andDehai Li*. Two New Cyclic Pentapeptides from the Marine Derived FungusAspergillus versicolor.Helv. Chim. Acta.2011,94, 1065-1070. Fazuo Wang#, Hongjuan Wei#, Tianjiao Zhu,Dehai Li, Zhenjian Lin and Qianqun Gu*. Three New Cytochalasins from the Marine-Derived FungusSpicaria elegansKLA03 by Supplementing the Cultures with L- and D-Tryptophan.Chem. Biodivers.2011, 8 (5), 887-894. Fazuo Wang,Dehai Li, Tianjiao Zhu, Min Zhang, Qianqun Gu*. Pseurotin A1and A2, two new 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-diones from the holothurian-derived fungusAspergillus fumigatusWFZ-25.Can. J Chem.2011, 89 (1), 72-76. Dehai Li, Shengxin Cai, Tianjiao Zhu, Fengping Wang, Xiang Xiao and Qianqun Gu*. New Cytotoxic Metabolites from a Deep-Sea-Derived Fungus,Phialocephalasp., Strain FL30r.Chem. Biodivers.2011, 8 (5), 895-901. Dehai Li, Gavin Carr, Yonghong Zhang, David E. Williams, Ashraf Amlani, Helen Bottriell, Alice L.-F. Mui, and Raymond J. Andersen*. Turnagainolides A and B, Cyclic Depsipeptides Produced in Culture by aBacillussp. Isolation, Structure Elucidation, and Synthesis.J. Nat. Prod.2011, 74 (5), 1093-1099. Shengxin Cai, Shiwei Sun, Huinan Zhou, Xianglan Kong, Tianjiao Zhu,Dehai Li*, and Qianqun Gu*. Prenylated polyhydroxy-p-terphenyls fromAspergillus taichungensisZHN-7-07.J. Nat. Prod.2011, 74 (5), 1106-1110. Lin Du#, Jing Ai#,Dehai Li, Tianjiao Zhu, Ying Wang, Michael Knauer, Torsten Bruhn, Hongbing Liu, Meiyu Geng,* Qianqun Gu,* and Gerhard Bringmann*. Aspergiolides C and D, Spirocyclic Aromatic Polyketides with Potent Protein Kinase c-Met Inhibitory Effects.Chem-Eur. J. 2011, 17 (4), 1319-1326. Shengxin Cai, Tianjiao Zhu, Lin Du, Boyu Zhao,Dehai Li*and Qianqun Gu*. Sterigmatocystins from the deep-sea-derived fungusAspergillus versicolor.J. Antibiot.2011, 64 (2), 193-196. Xiang Zeng, Xiang Xiao,Dehai Li, Qianqun Gu and Fengping Wang*. Isolation, identification and screening of microorganisms for cytotoxic activities from deep sea sediments at different pacific stations.World J. Microb. Biot.2010, 26, 2141-2150. Hongchun Liu#, Lin Du#, Tianjiao Zhu,Dehai Li, Meiyu Geng, Qianqun Gu*. Two NewCitrininDimersfrom a Volcano Ash-Derived FungusPenicillium citrinumHGY1-5.Helv. Chim. Acta.2010,93, 2224-2230. Lin Du,Dehai Li, Guojian Zhang, Tianjiao Zhu, Jing Ai, Qianqun Gu*. Novel carbon-bridged citrinin dimers from a volcano ash-derived fungusPenicillium citrinumand their cytotoxic and cell-cycle arrest activities.Tetrahedron2010, 66, 9286-9290. Lina Zhou, Tianjiao Zhu, Shengxin Cai, Qianqun Gu, andDehai Li*. Three New Indole-Containing Diketopiperazine Alkaloids from a Deep-Ocean Sediment Derived FungusPenicillium griseofulvum.Helv. Chim. Acta.2010, 93, 1758-1763. Dehai Li, Shengxin Cai, Tianjiao Zhu, Fengping Wang, Xiang Xiao, and Qianqun Gu*. Three new sorbicillin trimers, trisorbicillinones B, C and D, from a deep ocean sediment derived fungus,Phialocephalasp. FL30r.Tetrahedron2010, 66 (27-28), 5101-5106. Lin Du, Teng Feng, Boyu Zhao,Dehai Li, Shengxin Cai, Tianjiao Zhu, Fengping Wang, Xiang Xiao, and Qianqun Gu*. Alkaloids from a deep ocean sediment-derived fungusPenicilliumsp. and their antitumor activities.J. Antibiot.2010, 63 (5), 165-170. Shengxin Cai,Dehai Li, Tianjiao Zhu, Fengping Wang, Xiang Xiao and Qianqun Gu*. Two New Indole Alkaloids from Marine Derived Bacterium,Aeromonassp. CB101.Helv. Chim. Acta. 2010, 93, 791-795. Lin Du,Dehai Li,Tianjiao Zhu, Shengxin Cai, Fengping Wang, Xiang Xiao, Qianqun Gu*. New alkaloids and diterpenes from a deep ocean sediment derived fungusPenicilliumsp.Tetrahedron2009, 65, 1033-1039. Dehai Li,Fengping Wang, Xiang Xiao, Qianqun Gu*, and Weiming Zhu*. Trisorbicillinone A, a novel sorbicillin trimer, from a deep sea fungus，Phialocephalasp.FL30r.Tetrahedron. Lett.2007,48 (30),5235-5238. Dehai Li, Fengping Wang, Xiang Xiao, Shengxin Cai, Qianqun Gu*, and Weiming Zhu*. Two new bisorbicillinoids isolated from a deep sea fungus，Phialocephalasp.FL30r.J. Antibiot.2007, 60 (5), 317-320. Dehai Li,Fengping Wang, Xiang Xiao, Xiang Zeng, Qianqun Gu*, and Weiming Zhu*. A new cytotoxic phenazine derivative from a deep sea bacteriumBacillussp.Arch. Pharm. Res.2007, 30 (5), 552-555. Dehai Li, Shengxin Cai, Li Tian, Zhenjian Lin, Tianjiao Zhu, Yuchun Fang, Peipei Liu, Qianqun Gu*, and Weiming Zhu*. Two new metabolites with cytotoxicities from deep-sea fungus,Aspergillus sydowiYH11-2.Arch. Pharm. Res.2007, 30 (9), 1051-1054. Rui Liu, Tianjiao Zhu,Dehai Li, Xiaoxian Han, Jingyan Gu, Wei Xia, Yuchun Fang, Hongbing Liu, and Weiming Zhu*, and Qianqun Gu*. Two Indolocarbazole Alkaloids with Apoptosis Activity from a marine-derived Actinomycete Z2039-2.Arch. Pharm. Res.2007, 30 (4), 270-274. Juan Chen, Tiaonjiao Zhu,Dehai Li, Chengbin Cui, Yuchun Fang, Hongbin Liu, Peipei Liu, Qianqun Gu *, and Weiming Zhu *. Constructure of a metagenomic DNA library of sponge symbionts and screening of antibacterial metabolites.J. Ocean U. China2006, 5 (2), 119-122. Dehai Li,Tianjiao Zhu, Yuchun Fang, Hongbing Liu, Qianqun Gu * and Weiming Zhu *. The Antitumor Components from Marine-derived BacteriumStreptoverticillium luteoverticillatum11014 II.J. Ocean U. China2007, 6 (2), 193-195. Dehai Li, Tianjiao Zhu, Hongbing Liu, Yuchun Fang, Qianqun Gu*, and Weiming Zhu*. Four butenolides as new cytotoxic compounds from marine-derived bacteriaStreptoverticillium luteoverticillatum11014.Arch. Pharm. Res. 2006, 29 (8), 624-626. 海洋天然药物化学研究 [海洋信息资源服务平台] → 中国 → 山东 → 青岛 海洋生物医药业;海洋药物原药制造; 中国海洋大学 博士学位 2018-09-22 17:18:03