侯虎 侯虎，男，博士，副教授，硕士生导师。 联系电话：0532-82031936 邮箱：houhu@ouc.edu.cn；houhuouc@163.com 一、个人简历 _bull;2006-2011，中国海洋大学，食品科学与工程学院(硕博连读)，博士； _bull;2011-2014，中国海洋大学，食品科学与工程学院，讲师； _bull;2014-至今，中国海洋大学，食品科学与工程学院，副教授； _bull;2016-2017，Purdue University，农业与生物工程系、食品科学系，访问学者 围绕_ldquo;海洋功能蛋白_rdquo;进行研究，近年来先后承担科研项目20余项，其中作为负责人的科研项目13项，在国内外知名期刊发表学术文章85篇，其中以第一或通讯作者发表的SCI/EI文章37篇，曾获_ldquo;海洋科学技术进步一等奖_rdquo;1项、_ldquo;海洋科学技术进步二等奖_rdquo;1项、_ldquo;山东省科技进步二等奖_rdquo;1项、_ldquo;青岛市科技进步一等奖_rdquo;1项等；担任国际著名期刊Trends Food Sci Tech、Food Chem、J Funct Foods、J Agr Food Chem、Food Funct等评审专家、IFT会员、青岛生物工程学会理事等。 二、教学情况 主讲本科生课程《食品工程原理》、《食品工程原理实验》，研究生课程《食品蛋白质理论与技术》，主持教学项目3项，建立了以学生为中心的理论与实践相结合的教学体系；指导SRDP项目、国创项目10余项，多次评为优秀指导教师。 三、科研情况 1、主要研究方向 主要研究方向为_ldquo;海洋功能蛋白(肽)的基础理论与加工_rdquo;、_ldquo;海洋生物活性物质_rdquo;、_ldquo;胶原物理化学特性及应用_rdquo;等。围绕海洋生物蛋白，研究其组织结构特征、加工体系的变异性及热稳机制、目标蛋白（肽）的获取、结构解析与功能基因定位、生物活性及构效评价等。 2、主要科研课题 近年来，先后主持、参加国家自然科学基金、国家863计划课题、省重点研发计划、国家支撑计划课题及其他部委项目等24项课题研究，其中作为负责人承担项目13项。近期在研或完成的部分项目如下： _bull;国家自然科学基金：鳕鱼皮肽对光老化皮肤基质胶原降解的拮抗机制及活性中心结构解析。（负责人） _bull;国家自然科学基金：高温高压即食海参体壁非酶自降解途径及其拮抗机制。（负责人） _bull;山东省海洋经济创新发展区域示范项目：海洋活性蛋白及其功能制品的开发与产业化。（子课题负责人） _bull;山东省重点研发计划项目：针对肿瘤人群的深海鱼低聚肽制备关键技术及肿瘤全营养配方食品开发。（负责人） _bull;山东省自然科学基金：海参体壁热敏凝胶的自裂解特征及阻断机制研究。（负责人） _bull;教育部博士点基金：基于MAPK通路的大马哈鱼皮活性肽抗皮肤光老化机制。（负责人） _bull;山东省重点研发计划项目：海洋功能肽的关键制备技术及创伤、感染、手术及其他应激状态全营养配方食品的研发。（子课题负责人） _bull;中国博士后特别资助项目：刺参胶原凝胶聚集态的分子交联与热特性的耦合性研究。（负责人） _bull;青岛海洋生物医药研究院项目：鱼皮源脱细胞真皮基质口腔修复膜制备及引导牙槽骨再生机理研究。（负责人） _bull;中国博士后面上项目：刺参胶原蛋白的聚集态表征及热稳性能研究。（负责人） _bull;中央高校青年教师科研专项项目：大马哈鱼皮BIO-ANNs靶向活性肽对光老化皮肤MMPs拮抗机制研究。（负责人） _bull;国家自然科学基金：具有骨密度增加作用的鱼卵唾液酸糖肽化学结构解析和作用机制研究。（项目骨干） _bull;国家自然科学基金：鳕鱼源螯合肽促矿物质吸收和转运机制及分子机理。（项目骨干） _bull;国家863项目：高活性鱼骨钙肽螯合物制备关键技术研究与开发。（项目骨干） _bull;国家自然科学基金：壳寡糖金属配合物对肽键的水解作用。（项目骨干） _bull;国家自然科学基金：海藻中黄酮类化合物的分离鉴定及活性研究。（项目骨干） _bull;国家科技支撑计划：神经细胞功能调节食品成分的制备关键技术、活性评价及其应用。（项目骨干） 3、主要学术论文、专利 近年来，在国内外知名期刊发表学术文章85篇，其中SCI/EI文章50余篇，以第一或通讯作者发表文章40余篇，申请专利20余项，出版学术专著1部。 以第一或通讯作者发表的代表性文章如下： _bull;Effect of calcium-binding peptide from pacific cod (Gadus macrocephalus) bone on calcium bioavailability in Rats. Food Chemistry, 2017, 221, 373_ndash;378. _bull;Purification and identification of immunomodulating peptides from enzymatic hydrolysates of Alaska pollock frame. Food Chemistry, 2012, 134(2), 821_ndash;828. _bull;Moisture absorption and retention properties, and activity in alleviating skin photodamage of collagen polypeptide from marine fish skin. Food Chemistry, 2012, 135(3), 1432-1439. _bull;A novel calcium-binding peptide from Antarctic krill protein hydrolysates and identification of binding sites of calcium peptide complex. Food Chemistry, 2018, 243, 389-395. _bull;The effect of pacific cod (Gadus macrocephalus) skin gelatin polypeptides on UV radiation-induced skin photoaging in ICR mice. Food Chemistry, 2009, 115, 945_ndash;950. _bull;Immunomodulatory activity of Alaska pollock hydrolysates obtained by glutamic acid biosensor - artificial neural network and the identification of its active central fragment. Journal of Functional Foods. 2016, 24, 37-47. _bull;Protective effect of gelatin polypeptides from Pacific cod (Gadus macrocephalus) against UV Irradiation-Induced damages by inhibiting inflammation and improving transforming growth factor-_beta;/Smad signaling pathway. Journal of Photochemistry and Photobiology B: Biology. 2016, 162, 633_ndash;640. _bull;Protective effect of gelatin peptides from pacific cod skin against photoaging by inhibiting the expression of MMPs via MAPK signaling pathway. Journal of Photochemistry _amp; Photobiology, B: Biology. 2016, 165, 34_ndash;41. _bull;Effect of moisture status on the stability of thermal gels from the body wall of sea cucumbers (Apostichopus japonicus).LWT-Food Science and Technology, 2016, 74, 294-302. _bull;Nile tilapia skin collagen sponge modified with chemical cross-linkers as a biomedical hemostatic material. Colloids and Surfaces B: Biointerfaces, 2017,159, 89-96. _bull;Characterization of Pacific cod (Gadus macrocephalus) skin collagen and fabrication of collagen sponge as a good biocompatible biomedical material. Process Biochemistry, 2017, 63, 229-235. _bull;Effects of cross-linking on mechanical, biological properties and biodegradation behavior of Nile tilapia skin collagen sponge as a biomedical material. Journal of the Mechanical Behavior of Biomedical Materials, 2018. _bull;Thermal degradation behavior of collagen from sea cucumber (Stichopus japonicus) using TG-FTIR analysis. Thermochimica Acta, 2018, 659, 166_ndash;171. _bull;Identification of MMP-1 inhibitory peptides from cod skin gelatin hydrolysates and the inhibition mechanism by MAPK signaling pathway. Journal of Functional Foods, 2017, 33, 251-260. _bull;Characterization of acid- and pepsin-soluble collagen extracted from the skin of Nile tilapia (Oreochromis niloticus), International Journal of Biological Macromolecules, 2017, 99, 8-14. _bull;Effects of early enteral nutrition supplemented with collagen peptides on post-burn inflammatory responses in a mouse model. Food _amp; Function, 2017, 8, 1933_ndash;1941. _bull;Enzymatic hydrolysis of defatted mackerel protein with low bitter taste. Journal of Ocean University of China, 2011, 10, 85-92 _bull;Inhibition of melanogenic activity by gelatin and polypeptides from pacific cod skin in B16 melanoma cells. Journal of Food Biochemistry, 2011, 35, 1099_ndash;1116. _bull;Identification of Volatile Compounds in Antarctic Krill (Euphausia superba) using Headspace Solid-phase Microextraction and GC-MS. International Journal of Food Properties, 2017, 20(S1), S820_ndash;S829. _bull;Response Surface Optimization of Enzymatic Hydrolysis of Silver Sillago (Sillago sihama) with Low Bitter Taste. International Journal of Food Engineering, 2011, 7, Article 2. _bull;Proteins characteristics and lipid profiles of silver sillago (Sillago sihama). IEEE, 2011, 7738-7741. _bull;Optimization of enzymatic hydrolysis of Alaska pollock frame for preparing protein hydrolysates with low-bitterness. LWT-Food Science and Technology, 2011, 44, 421-428. _bull;Preparation of immunomodulatory hydrolysates from Alaska pollock frame. Journal of the Science of Food and Agriculture, 2012，92(15)，3029_ndash;3038. _bull;Solid-phase microextraction method for the determination of volatile compounds in hydrolysates of Alaska pollock frame. International Journal of Food Properties, 2013, 16, 790-802. _bull;Nonenzymatic softening mechanism of collagen gel of sea cucumber (Apostichopus japonicus). Journal of Food Processing and Preservation, 2015, 39(6), 2322_ndash;2331. _bull;Protective effect of cod (Gadus macrocephalus) skin collagen peptides on acetic acid-induced gastric ulcer in rats. Journal of Food Science. 2016, 81(7), H1807_ndash;H1815. _bull;Self-degradation of sea cucumber body wall under 4C storage condition. Journal of Food Processing and Preservation, 2016, 40(4), 715-723. _bull;Protective effect of gelatin and gelatin hydrolysate from salmon skin on UV irradiation-induced photoaging of mice skin. Journal of Ocean University of China. 2016 15 (4): 711-718. _bull;Enzymatic hydrolysis of Alaska Pollock proteins based on kinetics model and lysinebiosensor - neural network model. Journal of Aquatic Food Product Technology. 2017, 26, 3, 267_ndash;278. _bull;Effects of heat treatment on the gel properties of the body wall of sea cucumber (Apostichopus japonicus). Journal of Food Science and Technology, 2017, 54(3), 707_ndash;717. _bull;Analyzing the flavor compounds in Chinese traditional fermented shrimp pastes by HS-SPME- GC/MS and electronic nose. Journal of Ocean University of China, 2017, 16(2), 311-318. _bull;Characterization of protease and effects of temperature and salinity on the biochemical changes during fermentation of Antarctic krill. Journal of the Science of Food and Agriculture. 2017, 97: 3546_ndash;3551. _bull;大孔聚苯乙烯吸附树脂对鳕鱼排免疫活性肽的脱盐.过程工程学报, 2010, 10, 899-904. _bull;基于特征粘度的鳕鱼骨胶原蛋白酶解预测模型.农业机械学报, 2014, 45(3), 218-223. _bull;超高压处理对海参体壁凝胶稳定性及其劣化的影响.农业工程学报, 30(22), 316-322. _bull;复合酶酶解体系下大马哈鱼皮明胶酶解预测模型的建立.中国科技论文,2016,11, 1348 -1352. _bull;基于酶传感器-人工神经网络的胶原蛋白酶解监控模型.中国食品学报, 2016,16, 167-173. _bull;刺参胶原蛋白的结构特征与聚集行为的耦合性研究.中国食品学报,2017,(03):28-37. _bull;海参胶原纤维形态及胶原蛋白理化性质研究.现代食品科技, 2013, 29 (7), 1491-1495. _bull;磷酸化与钙交联处理对刺参胶原聚集体凝胶特性的影响,现代食品科技, 2015, 31(10): 190-195. _bull;鱼皮明胶抗紫外线损伤引起的皮肤光老化研究.现代食品科技, 2016, 32, 33-39. 海洋功能蛋白(肽)的基础理论与加工;海洋生物活性物质 [海洋信息资源服务平台] → 中国 → 山东 → 青岛 海洋生物医药业; 中国海洋大学 博士学位 2018-09-19 19:45:09