胡晓丽 胡晓丽 博士，教授，博士生导师 研究方向：贝类分子遗传学 联系方式 电话：0532-82031970 邮箱：hxl707@ouc.edu.cn 地址：青岛市鱼山路5号中国海洋大学化学馆224室 一、学习及工作经历 1989.9－1993.7青岛海洋大学水产学院食品工程专业，获学士学位 1993.9－2000.8青岛市农业科学研究所工作 2000.9－2005.6中国海洋大学海洋生命学院海洋生物学专业，获博士学位 2005.7－至今 中国海洋大学海洋生命学院工作 2009.8－2010.8美国斯坦福大学生物系访问学者 二、近三年主要科研项目 1.国家重点基础研究发展规划项目计划（973计划）：贝类分子设计育种的关键技术研究（2010CB126406），2012-2014，主持 2.国家自然科学基金：引种日本皱纹盘鲍对我国本土种质资源遗传结构影响的研究（41176118），2012-2015，主持 3.国家自然科学基金：栉孔扇贝抑肌素myostatin及其信号途径基因的表达调控（30972239），2010-2012，主持 4.国家高技术研究发展计划（863计划）重大项目：海洋生物分子细胞育种关键技术（2012AA10A402），2012-2015，第二位 5.国家重点基础研究发展规划项目计划（973计划）：贝类SNP规模发掘及高密度遗传连锁图谱的构建（2010CB126402），2010-2011，第三位 三、近五年发表论文（*通讯作者） 1. Liying Feng, Xue Li, Qian Yu, Xianhui Ning, Jinzhuang Dou, Jiajun Zou, Lingling Zhang, Shi Wang, Xiaoli Hu*, Zhenmin Bao*. A Scallop IGF Binding Protein Gene: Molecular Characterization and Association of Variants with Growth Traits. PLoS ONE. 2014; 9(2): e89039. 2. Wenqian Jiao, Xiaoteng Fu, Jinqin Li, Ling Li, Liying Feng, Jia Lv, Lu Zhang, Xiaojian Wang, Yangping Li, Rui Hou, Lingling Zhang, Xiaoli Hu, Shi Wang*, Zhenmin Bao*. Large-scale development of gene-associated single-nucleotide polymorphism markers for molluscan population genomic, comparative genomic, and genome-wide association studies. DNA Research. 2014. 21(2):183-193. 3. Xiaoteng Fu, Yan Sun, Jing Wang, Qiang Xing, Jiajun Zou, R Li, Z Wang, Shi Wang, Xiaoli Hu, Lingling Zhang*, Zhenmin Bao*. Sequencing-based gene network analysis provides a core set of gene resource for understanding thermal adaptation in Zhikong scallop Chlamys farreri. Molecular Ecology Resources. 2014. 14(1): 184_ndash;198. 4. Yueyue Zhang, Lingling Zhang, Jin Sun, Jianwen Qiu, Xiaoli Hu, Jingjie Hu, Zhenmin Bao*. Proteomic analysis identifies proteins related to carotenoid accumulation in Yesso scallop (Patinopecten yessoensis). Food Chemistry. 2014. 147: 111-116. 5. Jessica Chang, Yiqi Zhou, Xiaoli Hu, Lucia Lam, Cameron Henry, Erin M. Green, Ryosuke Kita, Michael S. Kobor, Hunter B. Fraser*. The molecular mechanism of a cis-regulatory adaptation in yeast. PLoS Genetics. 2013. 9(9):e1003813. 6. Jia Lv, Liying Feng, Zhenmin Bao, Huihui Guo, Yueyue Zhang, Wenqian Jiao, Lingling Zhang, Shi Wang, Yan He*, Xiaoli Hu*. Molecular characterization of RXR (Retinoid X Receptor) gene isoforms from the bivalve species Chlamys farreri. PLoS ONE. 2013. 8(9): e74290. 7. Liying Feng, Qian Yu, Xue Li, Xianhui Ning, Jing Wang, Jiajun Zou, Lingling Zhang, Shi Wang, Jingjie Hu, Xiaoli Hu*, Zhenmin Bao. Identification of reference genes for qRT-PCR analysis in Yesso scallop Patinopecten yessoensis. PLoS ONE. 2013. 8(9): e75609. 8. Yan He, Zhenmin Bao, Huihui Guo, Yueyue Zhang, Lingling Zhang, Shi Wang, Jingjie Hu, Xiaoli Hu*. Molecular cloning and characterization of SoxB2 gene from Zhikong scallop Chlamys farreri. Chinese Journal of Oceanology and Limnology. 2013. 31(6):1216-1225. 9. Shan Wang, Rui Hou, Zhenmin Bao, Huixia Du, Yan He, Hailin Su, Yueyue Zhang, Xiaoteng Fu, Wenqian Jiao, Yan Li, Lingling Zhang, Shi Wang*, Xiaoli Hu*. Transcriptome sequencing of Zhikong Scallop (Chlamys farreri) and comparative transcriptomic analysis with Yesso Scallop (Patinopecten yessoensis). PLoS ONE. 2013. 8(5): e63927. 10. Jiqin Li, Zhenmin Bao, Ling Li, Xiaojian Wang, Shi Wang, Xiaoli Hu*. Development of 101 novel EST-derived single nucleotide polymorphism markers for Zhikong scallop, Chlamys farreri. Journal of Ocean University of China. 2013. 12 (3): 403-412. 11. Huihui Guo, Zhenmin Bao, Huixia Du, Lingling Zhang, Shi Wang, Luyang Sun, Xiaoyu Mou, Xiaoli Hu*. Identification of Cytochrome P450 (CYP) Genes in Zhikong Scallop (Chlamys farreri). Journal of Ocean University of China. 2013. 12(1): 97-102. 12. Junxia Mao, Jia Lv, Yan Miao, Changsen Sun, Liping Hu, Ru Zhang, Xiaoteng Fu, Lingling Zhang, Xiaoli Hu, Shi Wang*, Zhenmin Bao*. Development of a rapid and efficient method for non-lethal DNA sampling and genotyping in scallops. PLoS ONE. 2013. 8(7): e68096. 13. Xiaoteng Fu, Jinzhuang Dou, Junxia Mao, Hailin Su, Wenqian Jiao, Lingling Zhang, Xiaoli Hu, Xiaoting Huang, Shi Wang*, Zhenmin Bao*. RADtyping: An Integrated Package for Accurate De Novo Codominant and Dominant RAD Genotying in Mapping Populations. PLoS One. 2013. 8(11): e79960. 14. Wenqian Jiao, Xiaoteng Fu, Jinzhuang Dou, Hengde Li, Hailin Su, Junxia Mao, Qian Yu, Lingling Zhang, Xiaoli Hu, Xiaoting Huang, Yangfan Wang, Shi Wang*, Zhenmin Bao*. High-resolution linkage and quantitative trait locus mapping aided by genome survey sequencing: Building up an integrative genomic framework for a bivalve mollusc. DNA Research. 2013. Doi: 10.1091/dnares/dst043. 15. Yueyue Zhang, Ru Zhang, Jiajun Zou, Xiaoli Hu, Shi Wang, Lingling Zhang*, Zhenmin Bao*. Identification and characterization of four ferritin subunits involved in immune defense of the Yesso scallop (Patinopecten yessoensis). Fish and Shellfish Immunology. 2013. 34: 1178-1187. 16.李纪勤,包振民*,李玲,胡晓丽.栉孔扇贝EST-SNP标记开发及多态性分析.中国海洋大学学报. 2013. 43(1): 56-63. 17.窦锦壮,赵熙强,付晓腾,焦文倩,王南南,张玲玲,胡晓丽,王师*,包振民.测序错误和重复序列对无参照基因组单核苷酸多态性分型的影响.中国海洋大学学报. 2013. 43(5):120-124. 18.郭慧慧,包振民,连珊珊,贺艳,胡晓丽*.栉孔扇贝骨形态发生蛋白I型受体基因的克隆及表达分析.中国海洋大学学报. 2013. 43(5): 37-43. 19.吕佳，侯睿，李宁，王宸，张玲玲，胡晓丽，王师，包振民*.应用MSAP技术研究扇贝全基因组DNA甲基化水平.中国海洋大学学报. 2013. 43(8): 48-53. 20.封利颖,郭慧慧,李雪,于茜,胡晓丽,张玲玲,王师,包振民*.栉孔扇贝骨形态发生蛋白2基因的克隆及表达分析.中国海洋大学学报. 2013. 43(12): 48-55. 21. Huihui Guo, Zhenmin Bao, Jiqin Li, Shanshan Lian, Shi Wang, Yan He, Xiaoteng Fu, Lingling Zhang, Xiaoli Hu*. Molecular characterization of TGF-_beta; Type I receptor gene (Tgfbr1) in Chlamys farreri, and the association of allelic variants with growth traits. PLoS ONE. 2012. 7(11): e51005. 22. Xiaojian Wang, Xiaoli Hu, Jiqin Li, Ling Li, Rui Hou, Shi Wang, Lingling Zhang*, Zhenmin Bao. Characterization of 38 EST-derived SNP markers in Zhikong scallop (Chlamys farreri) and their cross-species utility in Yesso scallop (Patinopecten yessoensis). Conservation Genetics Resources. 2012. 4:747_ndash;753. 23. Lingling Zhang, Rui Hou, Hailin Su, Xiaoli Hu, Shi Wang*, Zhenmin Bao*. Network analysis of Oyster transcriptome revealed a cascade of cellular responses during recovery after heat shock. PLoS ONE. 2012. 7(4): e35484. 24. Qinglei Meng, Zhenmin Bao, Zhaoping Wang, Shi Wang, Jingjie Hu, Xiaoli Hu,Xiaoting Huang*. Growth and reproductive performance of triploid Yesso scallops (Patinopecten yessoensis) induced by hypotonic shock. Journal of Shellfish Research. 2012. 31 (4): 1-10. 25. Jinzhuang Dou, Xiqiang Zhao, Xiaoteng Fu, Wenqian Jiao, Nannan Wang, Lingling Zhang, Xiaoli Hu, Shi Wang, Zhenmin Bao*. Reference-free SNP calling: Improved accuracy by preventing incorrect calls from repetitive genomic regions. Biology Direct. 2012. 7: 17. 26. Huixia Du, Zhenmin Bao, Rui Hou, Shan Wang, Hailin Su, Jingjing Yan, Meilin Tian, Yan Li, Wen Wei, Wei Lu, Xiaoli Hu, Shi Wang*, Jingjie Hu*. Transcriptome sequencing and characterization for the sea cucumber Apostichopus japonicas (Selenka, 1867). PLoS ONE. 2012. 7(3): e33311. 27. Rui Hou, Zhenmin Bao, Shan Wang, Hailin Su, Yan Li, Huixia Du, Jingjie Hu, Shi Wang*, Xiaoli Hu*. Transcriptome sequencing and De Novo analysis for Yesso Scallop (Patinopecten yessoensis) using 454 GS FLX. PLoS ONE. 2011. 6(6): e21560. 28.包振民*，王明玲，李艳，张玲玲，胡晓丽，黄晓婷，胡景杰，王师.基于核基因组标记的群体遗传学研究中的数学分析方法.中国海洋大学学报. 2011. 41(11): 48-56. 29. Xiaoli Hu, Huihui Guo, Yan He, Shan Wang, Lingling Zhang, Shi Wang, Xiaoting Huang, Scott William Roy, Wei Lu, Jingjie Hu*, Zhenmin Bao. Molecular characterization of myostatin gene from Zhikong scallop Chlamys farreri (Jones et Preston 1904). Genes _amp; Genetic Systems. 2010. 85(3): 207-218. 30. Ning Li, Jingjie Hu, Shan Wang, Jie Cheng, Xiaoli Hu, Zhenyu Lu, Zhenjian Lin, Weiming Zhu, Zhenmin Bao*. Isolation and identification of the main carotenoid pigment from the rare orange muscle of the Yesso scallop. Food Chemistry. 2010. 118: 616-619. 31. Aibin Zhan, Jingjie Hu, Xiaoli Hu, Min Hui, Mingling Wang, Wei Peng, Xiaoting Huang , Shi Wang, Wei Lu, Changsen Sun and Zhenmin Bao*. Construction of microsatellite-based linkage maps and identification of size-related quantitative trait loci for Zhikong scallop (Chlamys farreri). Animal Genetics. 2009. 40: 821-831. 32. Aibin Zhan, Jingjie Hu, Xiaoli Hu, Zunchun Zhou, Min Hui, Shi Wang，Wei Peng，Mingling Wang，Zhenmin Bao*. Fine-scale population genetic structure of zhikong scallop (Chlamys farreri): Do local marine currents drive geographical differentiation? Marine Biotechnology. 2009. 11: 223-235. 33. Aibin Zhan, Zhenmin Bao, Xiaoli Hu, Wei Lu, Jingjie Hu. Methods comparison for microsatellite marker development: different isolation methods, different yield efficiency. Journal of Ocean University of China. 2009. 8(2):161-165. 34.孟庆磊,黄晓婷,赵海波,赵婷,李宁,王昭平,胡晓丽*,胡景杰,包振民.扇贝异源三倍体诱导.中国水产科学. 2009. 16(5): 718-727. 35.胡景杰,战爱斌,胡晓丽,陆维,黄晓婷,包振民*.几种养殖扇贝微卫星标记的研究进展.水产学报. 2009. 33(2): 348-356. 四、专利 1.胡晓丽,包振民,黄晓婷,王师,张玲玲,陆维,王扬帆.一种饵料藻自动培养与投加装置（专利号：201320395073.6） 2.黄晓婷,胡晓丽,王师,张玲玲,孟庆磊,王珊,包振民,胡景杰.一种栉孔扇贝基因的染色体定位方法（专利号：ZL 200810138645.6） 3. Zhenmin Bao, Shan Wang, Ning Li, Jingjie Hu, Rui Hou, Xiaoliang Ren, Xiaoli Hu, Wei Lu. Breeding Method for Orange-Adductor-Muscle Scallop. (美国专利号：US8544415B2) 4.包振民,王珊,胡景杰,胡晓丽,李纪勤,侯睿,付晓腾,陆维.一种大规模筛查扇贝SNP的方法（专利号：ZL 200910231573.4） 5.包振民,王珊,吴厚刚,胡景杰,李宁,侯睿,任晓亮,胡晓丽,陆维.一种橘红色闭壳肌扇贝的培育方法（专利号：ZL 200910231570.0） 6.包振民,胡晓丽,张玲玲,王师,郭慧慧,张月月.栉孔扇贝TGF-_szlig; I型受体基因及其SNP位点（申请号：201210439861.0） 7.包振民,胡晓丽,张玲玲,王师,黄晓婷,王扬帆,陆维.一种饵料藻自动培养与投加方法（申请号：201310097183.9） 8.包振民,张月月,张玲玲,胡晓丽,陆维.虾夷扇贝铁蛋白基因及其应用（申请号：201210385015.5） 五、奖励及称号 1.教育部新世纪人才（2009） 2.国家科技进步二等奖（第6受奖人，2008） 3.教育部科技进步一等奖（第3受奖人，2007） 4.青岛市科技进步一等奖（第3受奖人，2007） 5.中国海洋大学_ldquo;五四_rdquo;青年奖（2008） 贝类分子遗传学 [海洋信息资源服务平台] → 中国 → 山东 → 青岛 海洋生物医药业; 中国海洋大学 博士学位 2018-08-27 21:03:21